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Expert Comparison

Semaglutide vs Tirzepatide

Both are proven GLP-1 medications for weight loss. Here's how they compare — mechanism, results, side effects, and pricing.

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GLP-1 Weight Loss
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Side-by-side

Feature-by-feature comparison

Mechanism, clinical results, dosing, and REMEVi pricing — at a glance.

Feature Semaglutide Tirzepatide
Mechanism GLP-1 receptor agonist Dual GIP/GLP-1 agonist
Avg Weight Loss 14.9% body weight 22.5% body weight
Clinical Trial STEP 1 (68 weeks) SURMOUNT-1 (72 weeks)
Brand Names Ozempic, Wegovy Mounjaro, Zepbound
Dosing 0.25mg → 2.0mg weekly 2.5mg → 15mg weekly
REMEVi Price $219/mo, flat forever $319/mo, flat forever
Best For Steady, proven results Maximum weight loss

How it works

Semaglutide mimics the GLP-1 hormone, reducing appetite and slowing gastric emptying. Clinical trials showed an average 14.9% body weight loss over 68 weeks.

Dosage

Starts at 0.25mg weekly, gradually increasing to 2.0mg over 16-20 weeks.

14.9%
avg body weight loss
STEP 1 — 68 weeks
$219/mo
All-inclusive. No hidden fees.
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The Protocols · Los Protocolos

One price. No surprises.

One flat price at every dose. Most weight-loss programs raise your price every time your dose goes up — REMEVi never does. Visit, medication, coaching and shipping — one number. No separate membership fee. (Many programs add a $79–$149/mo membership on top of the medication price.)

★ FOUNDERS CHOICE · BEST VALUE
REMEVi welcome kit on cream marble: compounded semaglutide injection vial with deep teal cap and prescription label, deep teal velvet pouch, welcome card, and fresh eucalyptus
NPI VERIFIED
INJECTION · GLP-1

Semaglutide Injections

Provider-managed weekly injection. The same compounded GLP-1 as the big-brand competitors — with bilingual care, no insurance, no dose upcharges.

From $149 /mo
The same price at every dose — it never climbs when your dose does.
  • Monthly $219/mo
  • 12-Week $189/mo
  • 52-Week $149/mo
Visits, meds, coaching & shipping — all included
  • ✓ Bilingual care, every visit (EN · ES)
  • ✓ −5″ off the waist in trials¹
Free · no card required Learn more about this treatment →
Highly recommend their services, fast, efficient, and have had a great experience. Much more reasonably priced than the office my mom was seeing.
Christina V. Verified Google review
Safety information →
NEEDLE-FREE · FOR PILL PREFERRERS
REMEVi compounded oral semaglutide in a deep teal translucent prescription bottle with cream cap, on cream marble with scattered white tablets and fresh eucalyptus
NPI VERIFIED
ORAL TABLET · DAILY

Semaglutide Oral

Daily oral semaglutide. Same clinical oversight, same bilingual care — without the needle.

From $249 /mo
The same price at every dose — it never climbs when your dose does.
  • Monthly $349/mo
  • 12-Week $309/mo
  • 52-Week $249/mo
Visits, meds, coaching & shipping — all included
  • ✓ Daily tablet — no syringe, no fridge
  • ✓ Cancel anytime — no contracts
  • ✓ −5″ off the waist in trials¹
Free · no card required Learn more about this treatment →
Easy to use interface and started seeing results sooner than expected. I wish knew sooner how easy it could be. Thank you REMEVi Health.
Kevin M. Verified Google review
Safety information →
★ CLINICIANS' CHOICE · DUAL-AGONIST
REMEVi compounded tirzepatide injection vial with deep teal cap and prescription label, elevated on cream marble pedestal with eucalyptus and teal silk fabric
NPI VERIFIED
INJECTION · GLP-1 + GIP

Tirzepatide Injections

Dual-agonist tirzepatide. The strongest average loss in the GLP-1 category — provider-managed, bilingual care.

From $199 /mo
The same price at every dose — it never climbs when your dose does.
  • Monthly $319/mo
  • 12-Week $249/mo
  • 52-Week $199/mo
Visits, meds, coaching & shipping — all included
  • ✓ Dual-agonist (GLP-1 + GIP) — faster avg loss
  • ✓ NPI-verified compounding pharmacy
  • ✓ −20.9% body weight at 15 mg in trials¹
Free · no card required Learn more about this treatment →
Un servicio rapido puntual y efectivo muy agradecido con todo. Aqui tienen un cliente por largo.
elvin m. Verified Google review
Safety information →

¹ Clinical-trial results for semaglutide (STEP-1, NEJM 2021) and tirzepatide (SURMOUNT-1, NEJM 2022) — the active medications in REMEVi protocols, not REMEVi outcomes or guarantees. Compounded preparations are not FDA-approved and have not been studied as finished products. Individual results vary.

FAQ

Frequently asked questions

Tirzepatide (22.5% avg) showed greater weight loss than semaglutide (14.9% avg) in clinical trials. However, individual results vary and your licensed provider will help determine the best option for you.

Yes, your REMEVi licensed provider can help you transition between medications if needed. Some patients start with semaglutide and move to tirzepatide for enhanced results.

Both medications share similar GI side effects (nausea, constipation). Tirzepatide may have slightly higher rates initially due to dual mechanism, but most side effects are mild and temporary.

Tirzepatide is a newer, dual-mechanism medication with stronger clinical results. The higher cost reflects the more complex compounding process and stronger clinical profile.

Yes, both medications require a prescription from a licensed provider. REMEVi includes clinical review in your monthly price — no separate consultation fee.

Not Sure Which Is Right for You?

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From $149/mo on the 52-week plan · your price never goes up See if you qualify →
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Free · no card required